ADP-specific glucokinase () also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Pyrococcus furiosus converts D-glucose to its monophosphate, glucose 6-phosphate, by transferring a phosphate group from the cofactor, adenosine diphosphate (ADP), which is converted to adenosine monophosphate (AMP). A similar enzyme has also been found in Thermococcus kodakarensis, where it acts on glucosamine as well as glucose.
In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.
Structural studies Examples of the ADP-dependent glucokinase structure solved by x-ray crystallography include the enzyme from mouse PDB accession code 5CCF and Archaea .
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