Pantetheine hydrolase () is an enzyme characterised from kidney that catalyzes the hydrolysis of one of the two amide bonds in pantetheine, giving pantothenic acid and cysteamine:
The enzyme is part of the catabolism of pantethine (vitamin B5) and one product, cysteamine, is an antioxidant. In humans, the enzyme is a vanin-1 protein. It has a role in inflammatory diseases like asthma.
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1.
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