N-methyl-2-oxoglutaramate hydrolase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Pseudomonas species hydrolyses N-methyl-2-oxoglutaramic acid to α-ketoglutaric acid and methylamine. The reaction is reversible and N-methyl-2-oxoglutaramic acid can spontaneously cyclise to 5-hydroxy-N-methylpyroglutamic acid.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.
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