Nicotinamide-nucleotide amidase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Azotobacter vinelandii hydrolyses the nucleotide, nicotinamide mononucleotide, to give nicotinate mononucleotide and ammonia.
Manufacture of nicotinamide mononucleotide for use as a pharmaceutical drug has been studied and in this context its degradation by nicotinamide-nucleotide amidase is undesirable, so means to down-regulate the enzyme or remove its associated gene have been sought.
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase.
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