Methylthioadenosine nucleosidase () is an enzyme characterised from Lupinus luteus that catalyzes the hydrolysis of 5′-methylthioadenosine to S-methyl-5-thio-D-ribose and adenine.
The enzyme is widely present in plants, including rice and Arabidopsis thaliana. Inhibition of the enzyme has been studied as a way to control the bacterium Helicobacter pylori.
This enzyme is a hydrolase, specifically a glycosylase that hydrolyses N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase.
Structural studies As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .
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