The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reversible reaction
The enzyme characterised from rat liver hydrolyses fructose 2,6-bisphosphate to D-fructose 6-phosphate and orthophosphate. In Arabidopsis thaliana and rice, where it has a role in salt tolerance, the reaction catalysed is reversible, and in the direction from the monophosphate to the biphosphate is equivalent to phosphofructokinase 2, requiring adenosine triphosphate to provide the phosphate group. These reactions help regulate fatty acid biosynthesis in plants.
This enzyme is a hydrolase, specifically one acting on phosphoric monoester bonds. The systematic name is β-D-fructose-2,6-bisphosphate 2-phosphohydrolase. Other names in common use include fructose-2,6-bisphosphatase, and D-fructose-2,6-bisphosphate 2-phosphohydrolase.
Structural studies As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , and .
References