The enzyme choloyl-CoA hydrolase (EC 3.1.2.27) catalyzes the reaction
The enzyme characterised from human liver hydrolyses choloyl-CoA to the bile acid, cholic acid, and coenzyme A which form the thioester in the starting material. This reaction regulates the level of coenzyme A in the peroxisome.
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.
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