The enzyme chondro-6-sulfatase (EC 3.1.6.10) catalyzes the reaction
The enzyme characterised from Proteus vulgaris hydrolyses 4-deoxy-β-D-gluc-4-enuronosyl-(1→3)-N-acetyl-D-galactosamine 6-sulfate (1) to 4-deoxy-β-D-gluc-4-enuronosyl-(1→3)-N-acetyl-D-galactosamine (2) and sulfate. The reaction is part of the breakdown pathway for chondroitins.
This enzyme is a hydrolase, specifically one acting on sulfuric ester bonds. The systematic name is 4-deoxy-β-D-gluc-4-enuronosyl-(1→3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase.
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