Cephalosporin-C deacetylase (EC 3.1.1.41) is an enzyme that catalyzes the reaction
The enzyme characterised from the fungus Cephalosporium sp. M8650 hydrolyses cephalosporin C to deacetylcephalosporin C and acetic acid. This reaction has been used in the large-scale production of deacetylcephalosporin C and related compounds from available intermediates including 7-aminocephalosporanic acid.
This enzyme is a hydrolase, specifically one acting on carboxylic ester bonds. The systematic name is cephalosporin-C acetylhydrolase. Other names in common use include cephalosporin C acetyl-hydrolase, cephalosporin C acetylase, cephalosporin acetylesterase, cephalosporin C acetylesterase, cephalosporin C acetyl-esterase, and cephalosporin C deacetylase.
Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .
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