The enzyme 4-hydroxybenzoyl-CoA thioesterase (EC 3.1.2.23) catalyzes the reaction
The enzyme characterised from bacteria hydrolyses 4-hydroxybenzoyl-CoA to coenzyme A and 4-hydroxybenzoic acid, which form the thioester in the starting material. The reaction is part of a biochemical pathway that breaks down chloro-substituted benzoic acids including 4-chlorobenzoic acid in Pseudomonas species.
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is 4-hydroxybenzoyl-CoA hydrolase.
Structural studies As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and . The enzyme contains a so-called HotDog domain.
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