Three ships of the United States Navy have been named USS Des Moines, after the city of Des Moines, Iowa.
(C-15/PG-29), was a in service from 1904 to 1921. , a heavy cruiser, was renamed on 6 November 1944. , the lead ship of her class, was a heavy cruiser in service from 1948 to 1961 and scrapped between 2006 and 2007.