3-hydroxyanthranilate 4-C-methyltransferase () is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the 3-hydroxyanthranilic acid, is converted to 3-hydroxy-4-methylanthranilic acid. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase. This enzyme is also called 3-hydroxyanthranilate 4-methyltransferase. The reaction is part of the biosynthetic pathway to actinomycin in Streptomyces antibioticus
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