3-methylquercetin 7-O-methyltransferase () is an enzyme that catalyzes the chemical reaction

This is a methylation reaction in which 3-O-methylquercetin is converted to 3,7-dimethylquercetin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).

The enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase. Other names in common use include flavonol 7-O-methyltransferase, flavonol 7-methyltransferase, 7-OMT, S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone, 7-O-methyltransferase, and 3-methylquercitin 7-O-methyltransferase [mis-spelt]. It can be found in Chrysosplenium americanum (American Golden Saxifrage).

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