3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase () is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the indole alkaloid, 3-hydroxy-16-methoxy-2,3-dihydrotabersonine, is converted to desacetoxyvindoline in Catharanthus roseus. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase. Other names in common use include 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase, NMT, 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase, S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine, and N-methyltransferase. It participates in terpene indole and ipecac alkaloid biosynthesis.
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