In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (R)-2-hydroxystearic acid and oxidised nicotinamide adenine dinucleotide (NAD). Its products are 2-oxostearic acid, reduced NADH, and a proton. This reaction is important in fatty acid metabolism.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
See also (S)-2-hydroxy-fatty-acid dehydrogenase which acts on the enantiomer of the hydroxy acid.
References