De Magistris is a surname. Notable people with the surname include:
Fabrizio De Magistris (fl. 1595–1602), Italian sculptor Gianni De Magistris (born 1950), retired Italian water polo player Luigi De Magistris (cardinal) (1926–2022), Italian Roman Catholic archbishop Luigi de Magistris (politician) (born 1967), Italian politician and magistrate Pomponio de Magistris (died 1640), Italian Roman Catholic Bishop Simone de Magistris (died 1613), Italian painter and sculptor