Blackstone River is a river in the U.S. states of Massachusetts and Rhode Island.
Blackstone River may also refer to:
Rivers: Blackstone River (Alberta), Canada Blackstone River (Yukon), Canada, a tributary of the Peel Watershed
Other: Blackstone River Bikeway, a planned paved trail defining the course of the East Coast Greenway in the United States
See also Blackstone (disambiguation)