Mayadin District () is a district (mantiqah) administratively belonging to Deir ez-Zor Governorate, Syria. At the 2004 official census, the district had a population of 247,171.2004 official census Its administrative centre is the city of Mayadin.

Subdistricts The district of Mayadin is divided into three subdistricts or Nāḥiyas (population according to 2004 official census):

Mayadin Subdistrict (ناحية الميادين): population 86,091. Diban Subdistrict (ناحية ذيبان): population 65,079. Al-Asharah Subdistrict (ناحية عشارة): population 96,001.

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