Abu Kamal District () is a district of the Deir ez-Zor Governorate in northeastern Syria. The administrative centre is the city of Abu Kamal. At the 2004 census, the district had a population of 265,142.

The Euphrates divides the district, with Hajin and As-Souseh subdistricts being part of Jazira (Upper Mesopotamia) while Abu Kamal and Al-Jalaa subdistricts are part of the Shamiyah (the Syrian Desert). (NB The region Shamiyah is used by McIntosh to mean the Syrian Desert, or part thereof) Abu Kamal is an economically prosperous farming region with cattle-breeding, cereals, and cotton crops. It is home to the historical site Dura-Europos and the tell of the ancient kingdom of Mari.

Subdistricts The district of Abu Kamal is divided into four subdistricts or nawāḥī (population as of 2004): Abu Kamal Subdistrict (ناحية البوكمال): population 92,031. Hajin Subdistrict (ناحية هجين): population 97,870. Al-Jalaa Subdistrict (ناحية الجلاء): population 29,255. Al-Susah Subdistrict (ناحية السوسة): population 45,986.

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