The Hepatitis C stem-loop IV is part of a putative RNA element found in the NS5B coding region. This element along with stem-loop VII, is important (but not essential) for colony formation, though its exact function and mechanism are unknown.
See also Hepatitis C alternative reading frame stem-loop Hepatitis C virus (HCV) cis-acting replication element (CRE) Hepatitis C virus 3'X element Hepatitis E virus cis-reactive element
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