Lost Highway may refer to:
Film Lost Highway (film), a 1997 film by David Lynch Lost Highway (soundtrack), the soundtrack for the Lynch film Lost Highway (opera), a 2003 opera adaptation of Lynch's film
Music Lost Highway Records, a country music record label now part of Universal Music Group Nashville
Albums and EPs Lost Highway, a 2002 EP by Helldorado Lost Highway (Bon Jovi album), 2007 Lost Highway: The Concert, 2007 Lost Highway (Willie Nelson album), a 2009 compilation album
Songs "Lost Highway" (Leon Payne song), 1948, covered by Hank Williams "Lost Highway" (Angry Samoans song), 1988 "Lost Highway" (Bon Jovi song), 2007
Other uses Hank Williams: Lost Highway (musical), a stage musical based on the life of Hank Williams