ISEC may refer to:
Institute for Social and Economic Change in India Instituto Superior de Educação e Ciências in Portugal Instituto Superior de Engenharia de Coimbra in Portugal International Society for Ecology and Culture, a.k.a. Local Futures International Space Elevator Consortium International Structural Engineering and Construction Society Interdisciplinary Science and Engineering Complex, at Northeastern University United States Army Information Systems Engineering Command
See also CT510, a video game console previously known as the iSec (Sports Entertainment Center)