Kapwepwe is a surname. It may refer to:
Chileshe Kapwepwe, Zambian accountant and corporate executive Mulenga Kapwepwe or Mpundu Kapwepwe (born 1958), Zambian author, co-founder of the Zambian Women's History Museum. Daughter to Simon Kapwepwe Simon Kapwepwe (1922–1980), Zambian politician, Vice President of Zambia from 1967 to 1970
See also Simon Mwansa Kapwepwe International Airport, Ndola, northern Zambia