Lewis and Clark Highway may refer to:
Lewis and Clark Trail, a named highway approximating the path of Lewis and Clark in 1804-1806 Lewis and Clark Highway (Montana), a named highway in Montana
Lewis and Clark Highway may also refer to:
Lewis and Clark National Historic Trail, a route roughly marking the path of Lewis and Clark's journey Northwest Passage Scenic Byway, a scenic byway in Idaho Lewis and Clark Back Country Byway, a scenic byway in Idaho Sacajawea Historic Byway, a scenic byway in Idaho Sakakawea Scenic Byway, a scenic byway in North Dakota Lewis & Clark Scenic Byway, a scenic byway in Nebraska
See also Lewis and Clark (disambiguation)