Lokshin, Lockshin () is a Jewish surname. Notable people with the surname include:
Aleksandr Lokshin (1920–1987), Russian composer of classical music Arnold Lockshin (born 1939), American-born Russian scientist Mikhail Lockshin (born 1981), American-born Russian film director Richard A. Lockshin (born 1937), Retired American cell biologist Michael D. Lockshin (born 1937), Professor Emeritus of Medicine at Weill Cornell Medicine and the Director Emeritus of the Barbara Volcker Center for Women and Rheumatic Diseases Steve Lockshin (born 1966), American financial advisor