SMSS may refer to:
Session Manager Subsystem (smss.exe), a component of the Microsoft Windows NT operating system Switching and Management Subsystem, in wireless communication technology Squad Mission Support System, military robotic system developed by Western company Lockheed Martin St. Margaret's Secondary School, a government-aided autonomous girls' secondary school in Bukit Timah, Singapore Sailor Moon SuperS, the fourth season of the anime series Sailor Moon SkyMapper Sky Survey SQL Server Management Studio, used for configuring, managing, and administering all components within Microsoft SQL Server