Guffey is a surname. Notable people with the surname include:
Burnett Guffey (1905–1983), American cinematographer Cary Guffey (born 1972), American former child actor J. Roger Guffey (1929–2009), American lawyer and president of the Federal Reserve Bank of Kansas City James M. Guffey (1839–1930), American oilman and politician James Guffey (1982–2021), ring name Jimmy Rave, American professional wrestler Joseph F. Guffey (1870–1959), American businessman and politician
See also Guffey Coal Act Celebration Park, an archaeological park in Idaho with historic Guffey railroad bridge