Galifianakis () is a Greek surname of a family originating in the Heraklion (Ηράκλειο) region of Crete, Greece. Notable people with the name include:
Nick Galifianakis (politician) (1928–2023), American politician and Democratic U.S. Congressman from North Carolina between 1967 and 1973, uncle of Zach Nick Galifianakis (cartoonist) (born 1962), American cartoonist and artist who draws satirical cartoons, first cousin of Zach Zach Galifianakis (born 1969), American actor, comedian and writer