William Sheffield may refer to:
William Sheffield (academic) (c.1732–1795), English museum keeper and college provost William Sheffield (judge), American attorney and judge William Paine Sheffield Sr., U.S. Representative and Senator from Rhode Island William Paine Sheffield Jr., U.S. Representative from Rhode Island William Sheffield (fl. 1407–1421) for Rutland (UK Parliament constituency) William Sheffield (died 1646), MP for Hedon, 1614 and Thirsk (UK Parliament constituency), 1624 Will Sheffield (born 2000), English cricketer Bill Sheffield (1928–2022), American politician and former governor of Alaska