Mathewson is a surname. Notable people with the surname include:
Christy Mathewson (1880–1925), baseball player Courtney Mathewson (born 1986), water polo player Elisha Mathewson (1767–1853), US senator George Mathewson (born 1940), Chairman of the Royal Bank of Scotland Henry Mathewson (1886–1917), baseball pitcher Rhys Mathewson, New Zealand comedian Ron Mathewson (1944–2020), jazz musician
See also Christy Mathewson–Memorial Stadium Mathewson Farm