Serapion is a given name, a variant of Seraphin.

It may refer to:

Saints Serapion of Macedonia (died 195), martyr Serapion of Antioch, Patriarch of Antioch from 191 to 211 Serapion of Thmuis (c. 300–360), Christian monk and Bishop of Thmuis Serapion the Sindonite (died 356), Egyptian monk and saint Serapion of Algiers (1179–1240), English, possibly Scottish, Catholic Mercedarian priest and martyr

Others Serapion of Alexandria, 3rd century BC Greek physician Serapion (strategos), probably negotiated in 48 BC for Caesar with Achillas, strategos of Cyprus in 43 BC, executed in 41 BC Serapion, 3rd century neoplatonic philosopher, one of the disciples of Plotinus Yahya ibn Sarafyun, also known as Serapion the Elder, 9th century Christian physician Serapion the Younger, 12th or 13th century physician who wrote The Book of Simple Medicine (in Arabic) Serapion of Vladimir (died 1275), Russian Orthodox Bishop of Vladimir Serapion of Novgorod (died 1516), Russian Orthodox archbishop Serapion (Coptic bishop of Los Angeles) (born 1951), first hierarch and bishop of the Coptic Orthodox Diocese of Los Angeles Serapion Kolosnitsin (1964–2025), Russian Orthodox archbishop of Kokshetau and Akmola

See also Mara bar Serapion, 1st century Syriac Stoic philosopher Sarapion, an ancient port city in what is now south-central Somalia Saint Serapion (Zurbarán), an oil on canvas painting by the Spanish artist Francisco de Zurbarán Serapion Brothers, a literary movement in the early Soviet Union