De Smet or Desmet may refer to:
People De Smet (surname)
Places De Smet, South Dakota, a town in Kingsbury County, South Dakota, United States De Smet, Idaho, a town in Benewah County, Idaho, United States De Smet, an unincorporated community in Missoula County, Montana, United States Smethport, PA, the county seat of McKean County, Pennsylvania, United States
Other uses Desmet method, a method for restoring the colours of early silent films
De Smet Jesuit High School, Creve Coeur, Missouri, United States DeSmet (boat), a passenger boat in Glacier National Park