Cardinal Piccolomini may refer to:
Enea Silvio Piccolomini, cardinal-priest of Santa Sabina from 1456, became Pope Pius II () Francesco Piccolomini, cardinal-deacon of San Eustachio from 1460, became Pope Pius III ( 1503) Giovanni Piccolomini (1475–1537), cardinal from 1517 Celio Piccolomini (1609–1681), cardinal-priest of San Pietro in Montorio from 1664