S&T can refer to:

Terms Science and technology, the counterpart of R&D Switching and terminal railroad Signalling and Telecommunications or Signalling and Telegraphy in Railway signalling Sales and trading

University Missouri University of Science and Technology, often shortened to "Missouri S&T" or simply "S&T"

Companies S&T (company), an IT company from Austria S&T Motors, the former name for KR Motors, a motorcycle manufacturer in South Korea S&T Dynamics, machine-tools and auto parts manufacturer of South Korea S&T Bank, a regional bank in Pennsylvania, United States S&T Bank Arena, an arena in Indiana, Pennsylvania

Publications Sky & Telescope, a magazine Strategy & Tactics, a magazine

Media Sherri and Terri, characters from The Simpsons