Cottonmouth may refer to: Vipers Agkistrodon piscivorus (northern cottonmouth), a semiaquatic pit viper found in the southeastern United States. Agkistrodon conanti (Florida cottonmouth), a semiaquatic pit viper found on the Florida peninsula and southern Georgia.

Medical symptom Xerostomia, or dry mouth, a medical symptom

Arts and entertainment Fictional characters and elements Cottonmouth (Cornell Stokes), a supervillain in the Marvel Comics universe Cottonmouth (Burchell Clemens), a supervillain in the Marvel Comics universe O-Ren Ishii, or Cottonmouth, a character in the film Kill Bill: Volume 1 Cottonmouth, a character in the 1978 film Convoy Cottonmouth, a fictional city and the setting for Manhunt 2

Music "Cotton Mouth", a 1972 song by the Doobie Brothers from Toulouse Street "Cottonmouth", a 1996 song by the Melvins from Stag "Cottonmouth", a 2007 song by Emanuel from Black Earth Tiger "Cottonmouth", a 2008 song by Sam Sparro from Sam Sparro "Cottonmouth", a 2015 song by In Hearts Wake from Skydancer "Cottonmouth", a 2020 song by Tallah from Matriphagy

Television "Cottonmouth" (Justified), a 2011 episode of Justified

Technology

COTTONMOUTH, a modified USB cable used for espionage by the National Security Agency