William Vaughan may refer to:
William Vaughan (philanthropist) (died 1580), English landowner, farmer and philanthropist Sir William Vaughan (writer) (1575–1641), Welsh writer and colonial investor Sir William Vaughan (Royalist) (died 1649), English royalist commander in the First English Civil War William Gwyn Vaughan (1680s–1753), Welsh politician William Vaughan (MP) (c. 1707–1775), Member of Parliament for and Lord Lieutenant of Merioneth William Vaughan (merchant) (1752–1850), English West India merchant and author William Vaughan (bishop) (1814–1902), Roman Catholic Bishop of Plymouth William Wirt Vaughan (1831–1878), member of the United States House of Representatives William Wyamar Vaughan (1865–1938), British educationalist William Vaughan (footballer) (1898 – 1976), English footballer William E. Vaughan (1915–1977), American columnist and author William Vaughan (art historian) (fl. 1972–2015), British art historian William Edward Vaughan (fl. 1984–2013), Irish historian W. Harry Vaughan (1900–1993), founder of the Georgia Tech Research Institute
See also William Vaughn (disambiguation)