San Onofre or Santo Onofre may refer to:
Onuphrius, known as San Onofre in Spanish and Santo Onofre in Portuguese, 4th-century Egyptian hermit honored as a saint in the Roman Catholic Church San Onofre, Sucre, a municipality in the Sucre Department of Colombia San Onofre State Beach, located in San Diego County, California San Onofre Nuclear Generating Station (SONGS), a nuclear power plant adjacent to the state beach Caldas da Rainha — Santo Onofre e Serra do Bouro, one of the twelve civil parishes of Caldas da Rainha in Portugal Santo Onofre River, in Brazil