Charles Henderson may refer to:
Politicians Charles Henderson (Alabama politician) (1860–1937), American politician, Governor of Alabama, 1915–1919 Charles Henderson (Nevada politician) (1873–1954), U.S. Senator from Nevada Charles Henderson (Canadian politician) (1883–1957), Canadian member of Parliament Charles P. Henderson (1911–1990), mayor of Youngstown, Ohio Charles Henderson Yoakum (1849–1909), U.S. Representative from Texas
Scientists Charles Richmond Henderson (1848–1915), American sociologist Charles Roy Henderson (1911–1989), U.S. animal geneticist
Other Charles E. Henderson (1907–1970), American songwriter and composer Charles Henderson (historian) (1900–1933), British historian and antiquarian of Cornwall Charles Henderson (bishop) (1924–2006), Irish-born UK Roman Catholic bishop Charles W. Henderson (born 1948), author of books about Marine Corps sniper Carlos Hathcock and Vietnam Charles Henderson (American football) (born 1946), former head football coach of Delaware State University Charles Cooper Henderson (1803–1877), British painter of horses and coaches Charles Henderson (character), fictional character in the Henderson's Boys and CHERUB series Charles Hanford Henderson (1861–1941), American educator and author Charles Henderson (weightlifter) (1922–2019), Australian weightlifter Charlie Henderson (1870–?), English footballer Charles Henderson, organist and choirmaster of St. George's Church from 1955-?, New York City. Charles Arlin Leon Henderson, American child who disappeared from Moscow Mills, Missouri