The name Portnoy, sometimes spelled Portnoi, is a Jewish surname of Russian origin. The Russian word 'портной' translates as 'tailor'. The name may refer to:

People Ana Portnoy (1950–2020), Argentine photographer Constanza Portnoy (born 1980s), Argentinian photojournalist Daniel A. Portnoy (born 1956), American microbiologist Dave Portnoy (born 1977), American businessman, founder of Barstool Sports Edan Portnoy or Edan (born 1978), American rapper, DJ, and producer Eddy Portnoy, American expert on Jewish popular culture Elinor Portnoy, Israeli-born glass artist Elliott Portnoy (born 1965), American attorney Estee Portnoy, American businesswoman Ethel Portnoy (1927–2004), American-born Dutch writer Gary Portnoy (born 1956), American singer/songwriter Israel Portnoy (born 1990), English-born Israeli musician Jerry Portnoy (born 1943), American harmonica musician Mendy Portnoy (born 1992), English-born Israeli musician Michael Portnoy (born 1971), American performance artist Mike Portnoy (born 1967), American drummer and songwriter Steven Portnoy (born 1971), American journalist Suzanne Portnoy (born 1961), American erotic author Vladimir Portnoi (born 1931), Soviet gymnast

Fictional characters Alexander Portnoy, the protagonist of Philip Roth's 1969 novel Portnoy's Complaint. Jeff Portnoy, a fictional comedic actor played by Jack Black in the 2008 film Tropic Thunder. Frankie Portnoy, a fictional thief in Aden Polydoros' 2021 novel The City Beautiful. Portnoy, an anthropomorsized groundhog in the cartoon Bloom County .

Musical groups The Portnoy Brothers, British-Israeli folk rock duo formed in 2012