Piccinini is an Italian surname. Notable people with the surname include:
Alberto Piccinini (footballer) (1923−1972), Italian professional football player Alessandro Piccinini (1566 – c. 1638), Italian lutenist and composer Amelia Piccinini (1917–1979), Italian athlete Eduardo Piccinini (born 1968), Brazilian butterfly swimmer Francesca Piccinini (born 1979), Italian volleyball player Gaetano Piccinini (1904–1972), Italian priest of the Don Orione Congregation Gualtiero Piccinini (born 1970), Italian and American philosopher Marco Piccinini (born 1952), Monegasque personality, businessman and politician Marina Piccinini (born 1968), Italian American virtuoso flautist Patricia Piccinini (born 1965), Australian artist
See also Joe Piccininni (1922–1995), Canadian city councillor