Mandelstam or Mandelshtam () is a Jewish surname which may refer to:
Leonid Mandelstam (1879–1944), Russian theoretical physicist Mandel'shtam (crater), lunar crater named for Leonid Mandelstam Nadezhda Mandelstam (1899–1980), Russian writer, wife of Osip Mandelstam Osip Mandelstam (1891–1938), Russian poet Leon Mandelshtam (1819 – 1889), Russian poet and translator Rod Mandelstam (born 1942), South African-born tennis player Stanley Mandelstam (1928–2016), South African-born particle physicist Mandelstam variables, relativistically invariant representation for particle scattering, introduced by Stanley Mandelstam