Britton Chance (July 24, 1913 – November 16, 2010) was an American biochemist, biophysicist, scholar, and inventor whose work helped develop spectroscopy as a way to diagnose medical problems. He was "a world leader in transforming theoretical science into useful biomedical and clinical applications" and is considered "the founder of biomedical photonics." He received the National Medal of Science in 1974.
He also was an Olympic athlete who won a gold medal in sailing for the United States at the 1952 Summer Olympics in the 5.5 Metre Class.
Early life and education Chance was born in Wilkes-Barre, Pennsylvania. His parents were Eleanor Kent and Edwin Mickley Chance, president of United Engineers and Constructors, Inc, which built power plants. His father was also a mining engineer, chemist, and inventor who held a number of metallurgical patents and created a device that detected carbon monoxide in coal mines using a chemical reaction. Chance's paternal grandfather, Henry Martyn Chance, was a noted geologist and mining engineer who also had a medical degree.
When he was a teenager, the family moved to Haverford, Pennsylvania. His family had a summer home in Mantoloking, New Jersey where he learned to sail on his father's yacht Antares. He also sailed in Antilles and the Panama Canal Zone. When he was 13 years old, he became a licensed as a radiotelegraph operator and built his first powerful radio transmitter.
He graduated from the Haverford School in 1931. He attended the University of Pennsylvania where he received a bachelor's degree in physical chemistry in 1935, and a M.A. in microbiology in 1936. While at Penn, he was a member of St. Anthony Hall and of the professional and scientific honorary societies Alpha Chi Sigma, Sigma Tau, and Tau Beta Pi."Necrology" (PDF). The Review. St. Anthony Hall. Winter: 14. 2013. He was also the business manager of The Pennsylvania Triangle, the engineering, architecture, and science student magazine. As a graduate student he developed a microflow version of a stopped-flow apparatus.
Around the time he was 17, he invented an auto-steering device for ships, receiving a patent in 1937. He tested the device on a trip to the West Indies using his father's yacht in 1935. In March 1938, the General Electric CompanyThe British company GEC, not to be confused with the American company General Electric (GE). hired him to test the auto-steering device on a round trip from England to Australia on the MS New Zealand Star, a 20,000-ton refrigerator ship. In return, the company paid his tuition to Cambridge University.
In 1938, Chance enrolled in Cambridge University. He came back to the United States to visit his parents but was unable to return to Cambridge and England because of World War II. He returned to the University of Pennsylvania and received a Ph.D degree in physical chemistry in 1940.
In 1943, he received a second Ph.D. from Cambridge University in biology and physiology, followed by a D.Sc. from Cambridge in 1952.
Career In 1941, Chance became an assistant professor of biophysics and physical biochemistry in the school of medicine at the University of Pennsylvania. During World War II, he worked for the Radiation Laboratory at the Massachusetts Institute of Technology which was working on the development of radar. He became a member of the Steering Committee and head of the Precision Circuits Section, supervising some 300 physicists. They developed radar technology that allowed blimps to spot German submarines, as well as a "ground position indicator" to allow more accurate bombing. He also developed analog electronic computers to calculate non-linear processes and helped develop ENIAC, of the world's first general-purpose computer.
After World War II, he received a Guggenheim Fellowship that allowed him to work in Stockholm for two years with scientist Hugo Theorell at the Nobel Institute. Their work resulted in seven papers in the Journal of Biological Chemistry. It also let to Theorell winning the Nobel Prize in 1955.
In 1949, he became a professor of biophysics at the University of Pennsylvania School of Medicine and was appointed the second director of the Eldridge Reeves Johnson Foundation for Research in Medical Physics, a position he held until 1983. He was then appointed E. R. Johnson Professor of Biophysics and Physical Biochemistry (later renamed as Biochemistry and Biophysics) in 1964 and university professor in 1977.
Early in his career, Chance worked on enzyme structure and function, developing methods to study the pre-steady-state phase of reactions. He invented the now standard stopped-flow device to measure the existence of the enzyme-substrate complex in enzyme reaction.Kresge N, Simoni RD, Hill RL. Britton Chance: Olympian and Developer of Stop-Flow Methods. J. Biol. Chem., Vol. 279, Issue 50, 10, December 10, 2004. He is considered the founder of biomedical photonics, which is now a research field covering biology, medicine, and physics. Starting in the late 1980s, he developed various near-infrared spectroscopy and photon diffusion imaging methods. He was also a pioneer in the numerical simulations of biochemical reactions and metabolic pathways.Chance, B., Greenstein, D. S., Higgins, J. & Yang, C. C. The mechanism of catalase action. II. Electric analog computer studies. Arch. Biochem. Biophys. 37, 322–339 (1952).Chance, Britton and Garfinkel, David and Higgins, Joseph and Hess, Benno. Metabolic control mechanisms. V. A solution for the equations representing interaction between glycolysis and respiration in ascites tumor cells. Journal of Biological Chemistry. 235, 2726–2439 (1960) In the 2000s, he developed molecular imaging beacons for cancer detection and diagnosis, predicting cancer aggressiveness in muscles, breast tissue, and the brain.
Chance became an emeritus professor at the University of Pennsylvania in 1983. He became the president of the Medical Diagnostic Research Foundation in Philadelphia in 1995. He was visiting distinguished chair professor at National Cheng Kung University in Taiwan, from 2009 to 2010.
Publications Chance published about 392 articles with 28947 citations (h = 92) as of 19 May 2022. The following is a selection of his key papers: Chance, B. and Theorell, H. "Studies on liver alcohol dehydrogenase 2. The kinetics of the compound of horse liver alcohol dehydrogenase and reduced diphosphopyridine nucleotide." Acta Chemica Scandinavica. 5 (7–8): 1127—1144 (1951) Chance, B. and Williams, G. R. "Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization." Journal of Biological Chemistry. 217 (1) 383–393 (1955) Chance, B. and Williams, G.R. "The respiratory chain and oxidative phosphorylation." Advances in Enzymology and Related Subjects of Biochemistry. 17: 65–134 (1956) Chance, B; Ito, T. and Nishimura, M. "Studies on bacterial photophosphorylation 3. A sensitive and rapid method of determination of photophosphorylation." Biochimica et Biophysica Acta. 59 (1): 177–182 (1962) Chance, B. "Energy-linked reaction of calcium with mitochondria." Journal of Biological Chemistry. 240 (6): 27292728 (1965) Chance, B., Boveris, A. "Mitochondrial generation of hydrogen-peroxide – General properties and effect of hyperbaric-oxygen." Biochemical Journal. 134 (3): 707–716 (1973) Chance, B.; Sies, H. and Boveris, A. "Hydroperoxide metabolism in mammalian organs." Physiological Reviews. 59 (3): 527–605 (1979) Chance, B. and Yodh, A. "Spectroscopy and imaging with diffusing light." Physics Today. 48 (3): 34–40 (1995)
Professional affiliations Chance was elected to the United States National Academy of Sciences in 1950. He became a resident member of the American Philosophical Society in 1958, and served on President Dwight D. Eisenhower's Science Advisory Committee from 1959 to 1960.
He was elected as a foreign member of the Royal Swedish Academy of Sciences in Medical Sciences in 1968, the Wistar Institute in 1969, the German Academy of Sciences Leopoldina in 1971, the Royal Society in 1981, and The International Society for Optical Engineering in 2007. He also became a Fellow of the American Physical Society in 2007, and a Fellow in Institute for Corean-American Studies.
He was a Harvey Lecturer at the New York Academy of Medicine in 1954, a Phillips Lecturer at the University of Pittsburgh in 1956 and 1965, and a Pepper Lecturer at the University of Pennsylvania in 1957. In 1986, he gave the keynote address at the 152nd national meeting of the American Association for the Advancement of Science in Philadelphia.
He was a member of the American Academy of Arts and Sciences, the American Chemical Society, the Institute of Radio Engineers, and the Society of Biological Chemists. He cofounded the Biophysical Society and the Journal of Innovative Optical Health Sciences.
He was also vice president of the American Philosophical Society, chairman of the American Association for the Advancement of Science, president of the International Union of Pure and Applied Biophysics, president of the International Society of Oxygen Transport to Tissue, president for the Society for Free Radical Research International, and a board member of the International Federation of Institutes for Advanced Study.
Awards President's Certificate of Merit, 1950 Paul-Lewis Award in Enzyme Chemistry, Division of Biological Chemistry of the American Chemical Society, 1950 Morlock Award, Institute of Electrical & Electronics Engineers, 1961 Genootschapps Medaille, Dutch Biochemical Society, Netherlands, 1965 Harrison Howe Award, Rochester Section, American Chemical Society, 1966 Franklin Medal, Franklin Institute, 1966 John Price Wetherill Medal, Franklin Institute, 1966 Award for Excellence (Life Sciences), Pennsylvania, 1968 Philadelphia Section Award, American Chemical Society, 1969 Heineken Prize for Biochemistry and Biophysics, Netherlands Academy of Science and Letters,1970 Nichols Award, New York Section, American Chemical Society, 1970 Canada Gairdner International Award, Gairdner Foundation, Canada,1972 National Medal of Science, United States,1974National Science Foundation – The President's National Medal of Science Semmelweis Medal, Hungary, 1974 Award for Significant Contributions; Field of Biochemical Instruments, ISCO,1976 Kappa Delta Elizabeth Winston Lanier Award, American Academy of Orthopaedic Surgeons, 1986 Senior Investigator Award, American Heart Association, 1986 Gold Medal for Distinguished Service to Medicine, College of Physicians, 1987 Max Delbruck Prize in Biological Physics, American Physical Society, 1987 Gold Medal, International Society of Magnetic Resonance in Medicine, 1988 J. Henry Wilkinson Award, International Society for Clinical Enzymology, 1989 Benjamin Franklin Medal for Distinguished Achievement in the Sciences, American Philosophical Society, 1990 Christopher Columbus Discovery Award in Biomedical Research, National Institutes of Health, 1992 John Scott Award, City of Philadelphia, 1992 Honor Award, American College of Sports Medicine, 1999 Liberty Award, Institute for Corean-American Studies, 2005 Lifetime Achievement Award, International Society for Optical Engineering, 2005 Gold Medal, American Roentgen Ray Society, 2006 Distinguished Achievement Award, American Aging Association, 2006 Friendship Award, China, 2008 Molecular Imaging Achievement Award, Society for Molecular Imaging, 2008 International Science and Technology Cooperation Award, 2009
Honors The Stellar-Chance Laboratories at the University of Pennsylvania were named after him in 1995. He received honorary MDs from Karolinska Institute in 1962, University of Düsseldorf in 1991, University of Buenos Aires in 1993, University of Copenhagen in 1995, and University of Rome Tor Vergata in 1997.