Holy Island or Holy Isle may refer to:

Places

United Kingdom

England Holy Island, also known as Lindisfarne, Northumberland

Scotland Holy Isle, better known as Eileach an Naoimh, located in the Firth of Lorn Holy Island, Firth of Clyde, off the Isle of Arran

Wales Holy Island, Anglesey

Ireland Holy Island, better known as Inis Cealtra, in Lough Derg near Mountshannon, County Clare

United States Holy Island, Massachusetts Holy Island (Lake Charlevoix), Michigan

Other uses The Holy Island, a 1959 Indian Bengali-language film by Debaki Bose Holy Island, 2015 novel by LJ Ross