VPM may refer to:
Varying Permeability Model Vel Phillips Memorial High School, a public high school in Madison, Wisconsin Ventral posteromedial nucleus, a nucleus of the thalamus; part of the brain. Virginia Payload Module, a weapon system planned for Block 5 of the US Navy's Virginia-class submarine Volcanic passive margin VPM Media Corporation VPM SnC, an Italian autogyro company, renamed Magni Gyro in 1996 Vranken Pommery Monopole
Radio stations VPM-FM, a radio station in Belize Three related public radio stations in Virginia WBBT-FM, branded as VPM Music WWLB, branded as VPM Music WCVE-FM, branded as VPM News