The following is a list of independent pharmaceutical, biotechnology and medical companies listed on a stock exchange (as indicated) with current market capitalization of at least US$10 billion, ranked by their market capitalization.

It does not include biotechnology companies that are currently owned by, or form a part of, larger pharmaceutical groups.

Ranking by market capitalization The following table lists the largest biotechnology and pharmaceutical companies ranked by market capitalization in billion US dollars. The change column indicates the company's relative position in this list compared to their relative position in the preceding year; i.e., an increase would be moving closer to rank 1 and vice versa. +Largest biotechnology and pharmaceutical companies ranked by market capitalization in billion US dollars.RankChgCompanyCountryTraded onLargest1 Johnson & Johnson 399.9 (Dec 2020) 399.99 385.0 346.1 375.4 314.1 284.2 277.8 258.32 1 Roche 291.1 (Dec 2020) 291.12 281.1 209.3 216.7 192.1 234.7 258.5 240.33 2 Pfizer 310.5 (Jul 2000) 208.11 216.7 259.7 215.9 196.3 199.3 205.4 196.04 1 Novartis 275.2 (Jul 2015) 202.09 240.0 200.0 196.7 170.5 206.1 229.8 195.05 1 Merck & Co. 232.9 (Dec 2019) 201.80 232.9 205.8 153.3 164.3 147.6 166.9 146.56 Moderna 201 (Sep 2021)68.545.0 -7 Abbott Laboratories 190.4 (Dec 2020) 190.44 153.5 126.8 99.3 56.4 67.0 67.9 59.38 2 AbbVie 196.2 (Jan 2018) 182.27 130.9 146.3 154.4 100.2 96.8 104.1 83.89 Novo Nordisk 161.9 (Dec 2020) 161.99 137.1 111.9 131.2 92.6 153.9 125.4 -10 2 Eli Lilly & Co 158.3 (Dec 2020) 158.30 126.9 125.6 93.0 80.9 93.4 76.6 57.011 3 Bristol-Myers Squibb 137.8 (Dec 2020) 137.85 105.0 85.0 100.3 98.2 114.8 97.6 87.212 4 Amgen 145.8 (Dec 2019) 129.79 144.6 128.8 126.2 108.9 122.5 93.1 78.713 2 AstraZeneca 130.8 (Dec 2019) 129.44 130.8 96.2 87.9 68.8 85.8 88.9 74.614 4 Sanofi 151.3 (Sep 2014) 120.66 63.5 108.4 108.2 101.8 111.8 138.1 142.015 2 GlaxoSmithKline 174.9 (May 2006) 90.15 117.2 94.8 87.9 93.3 97.6 128.9 129.616 1 Stryker Corporation 88.8 (Dec 2020) 88.81 78.5 58.6 58.0 45.1 34.7 35.7 28.417 2 Zoetis 76.6 (Aug 2020) 75.97 63.2 41.4 35.1 26.4 23.8 21.6 16.318 3 Gilead Sciences 179.6 (Jun 2013) 71.93 82.3 81.6 93.6 96.6 145.8 109.0 78.419 6 Daiichi Sankyo 45.3 (Dec 2019) 63.92 45.3 22.7 27.5 35.3 38.8 33.2 28.7 20 1 Vertex Pharmaceuticals 78.9 (Jul 2020) 61.33 56.3 42.2 37.9 18.3 31.0 28.7 17.421 4 Bayer 129.0 (Mar 2015) 58.12 80.1 63.1 101.9 85.3 103.2 113.2 117.422 2 Takeda Pharmaceutical 61.5 (Dec 2019) 56.78 61.5 52.9 40.2 45.6 47.8 37.5 34.3 23 1 Illumina 56.0 (Jul 2019) 53.51 48.2 44.1 40.2 39.4 35.4 28.6 25.724 2 Regeneron Pharmaceuticals 61.4 (Aug 2015) 52.52 41.2 40.3 40.4 39.3 56.5 42.0 27.425 3 Biogen 111.7 (Mar 2015) 38.66 54.7 63.5 67.4 61.6 68.3 79.7 66.126 2 Alexion Pharmaceuticals 47.0 (Jul 2015) 33.52 24.3 21.7 26.7 27.4 43.1 36.7 26.027 3 Seagen 38.2 (Oct 2020) 34.44 19.5 13.828 1 Astellas 40.6 (Dec 2015) 27.5232.723.829.3 25.7 40.6 35.8 27.6 29 4 Genmab 25.9 (Nov 2020) 25.53 14.5 10.6 10.8 10.8 8.8 3.8 2.630 1 Eisai Pharmaceutical 37.3 (Dec 2016) 19.93 21.5 23.0 24.5 37.3 28.8 30.2 28.731 Alnylam Pharmaceuticals 23.36 18.5 24.0 21.0 16.0 -32 Incyte 31.2 (Mar 2017) 19.25 18.8 13.5 18.3 15.4 10.6 7.3 4.633 BioMarin 24.0 (Jul 2015) 16.03 15.2 15.1 18.3 20.4 13.8 12.9 10.834 BeiGene 33.14 (Nov 2021) 34.20 27.00 26.00 24.03 10.28 8.33 4.45 1.2035 1 BioNTech 44.07 62.52 19.62 7.68 -36 1 Horizon Therapeutics 18.06 (Dec 2020) 14.2 11.6 9.3 5.0 6.5 2.8 2.0 -37 1 10x Genomics 17.54 11.2 -38 1 Jiangsu Hengrui Medicine 41.17 59.98 93.42 60.85 30.53 30.54 16.79 15.10 -39 1 Elanco 13.06 (Nov 2020) 11.2 -40 1 Celltrion 23.03 (2021) 40.90 19.22 -41 1 Viatris 18.50 (Dec 2021) -42 1 Sun Pharma 27.15 (2021) 19.01 -43 1 Divi's Laboratories 15.29 (Nov 2021) -44 1 Dr. Reddy's Laboratories 10.94 (2021) 11.75 -45 31 Teva Pharmaceuticals 110.5 (Jul 2015) 10.69 48.3 16.2 24.4 32.7 13.2 70.5 29.346 1 Cipla 10.21 (Dec 2021) 10.19 -

– Biotechnology company – Pharmaceutical company

See also List of largest biomedical companies by revenue

References