SMO or Smo may refer to:
Biology Smoothened, a gene that encodes a protein of the same name Spermine oxidase, an enzyme Styrene monooxygenase, an enzyme
Computing and technology Sequential minimal optimization, an algorithm for training support vector machines Social media optimization Solar Monitoring Observatory, on the International Space Station SQL Server Management Objects for Microsoft SQL Server
Organizations Sabhal Mòr Ostaig, a Scottish Gaelic-medium public college on the Isle of Skye Slovak Youth Orchestra
Transport SMO, IATA airport code for Santa Monica Airport, USA SMO, National Rail station code for South Merton railway station, London
Other uses SMO, ITU country code for Samoa smo, ISO 639-3 code for the Samoan language Smo, former stage name of Sara Forsberg (born 1994), Finnish singer SMO, a character first appeared in the episode "Be More" of the animated series Adventure Time Senior Medical Officer, a rank in the British Royal Army Medical Corps Singapore Mathematical Olympiad, a mathematics competition Site management organization, a provider of services to an organization holding a clinical trial Social movement organization, a formal organization within a social movement Special military operation, the Russian government's name for the 2022 Invasion of Ukraine Super Mario Odyssey, a video game released for the Nintendo Switch Big Smo, stage name of American country rap musician John Smith (born 1976)