Wesker is a surname. Notable people with the surname include:
Arnold Wesker (1932–2016), English playwright Sarah Wesker (1901–1971), English trade unionist
Fictional characters Albert Wesker, a character in the video game series Resident Evil Alex Wesker, sister of Albert, a character in the video game series Resident Evil Arnold Wesker, the real name of the Ventriloquist, a Batman villain