GPO may refer to:

Government and politics United States Government Publishing Office Government Press Office (Israel) General Post Office, United Kingdom General Post Office, Dublin Social Security Government Pension Offset, a provision reducing benefits Government Pharmaceutical Organization, a Thai state enterprise Green Party of Ontario, Canada Group purchasing organization, a type of business consortium

Places Guam Premier Outlets, a shopping mall in Guam Indore G.P.O., a residential area in Indore, India General Pico Airport (IATA code: GPO) Gospel Oak railway station (National Rail code: GPO)

Science and technology Giant Pacific Octopus Group Policy Object General Purpose Outlet, the mains socket in Australia General-purpose output, an uncommitted digital signal pin on an integrated circuit or electronic circuit board used as an output and controllable by the user at runtime

Other uses Generalplan Ost, a Nazi plan for genocide in Eastern Europe Gun Position Officer, a lieutenant responsible for the technical control of an artillery battery in the United Kingdom and Commonwealth forces General Post Office (disambiguation)