James Ware may refer to:
Medicine James Ware (ophthalmologist) (1756–1815), English eye surgeon and Fellow of Royal Society James Ware (surgeon) (1941–2015), British surgeon and medical educator
Politics James Britton Ware (1830–1918), American senator from Georgia James Franklin Ware (1849–?), American politician
Sports Jim Ware (hurler) (1908–1983), Irish hurler Jim Ware (basketball) (1944–1986), American professional basketball player James Ware (born 1958), American professional wrestler better known as Koko B. Ware
Other James Ware (historian) (1594–1666), Irish historian James Redding Ware (1832–1900s), British novelist and playwright James E. Ware (1846–1918), American architect James H. Ware (1941–2016), American biostatistician and Dean of Harvard T.H. Chan School of Public Health James Ware (judge) (born 1946), United States district judge