SPIE is the Society of Photo-Optical Instrumentation Engineers, an international optical engineering society.
SPIE may also refer to: Special Patrol Insertion/Extraction, a military technique for insertion/extraction Spie Batignolles, France-based multinational engineering company SPIE Gold Medal, the highest honor of the International Society for Optics and Photonics SPIE Newsroom, a technical news website launched in March 2006